General Information

  • ID:  hor004150
  • Uniprot ID:  Q9PTS1
  • Protein name:  Corticoliberin
  • Gene name:  CRH
  • Organism:  Carassius auratus (Goldfish)
  • Family:  Sauvagine/corticotropin-releasing factor/urotensin I family
  • Source:  Animal
  • Expression:  hypothalamus
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Carassius (genus), Cyprininae (subfamily), Cyprinidae (family), Cyprinoidei (suborder), Cypriniformes (order), Cypriniphysae (superorder), Otophysi, Ostariophysi (subcohort), Otomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  SEEPPISLDLTFHLLREVLEMARAEQMAQQAHSNRKMMEIF
  • Length:  41(120-160)
  • Propeptide:  MKLNFLVTTVALLVAFPPPYECRAIEGSSNQPATDPDGERQSPPVLARLGEEYFIRLGNRNQNYLRSPADSFPETSQYSKRALQLQLTQRLLEGKVGNIGRLDGNYALRALDSVERERRSEEPPISLDLTFHLLREVLEMARAEQMAQQAHSNRKMMEIFGK
  • Signal peptide:  MKLNFLVTTVALLVAFPPPYECRA
  • Modification:  T41 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Regulate the release of corticotropin from pituitary gland
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q9PTS1-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004150_AF2.pdbhor004150_ESM.pdb

Physical Information

Mass: 554223 Formula: C209H337N59O64S4
Absent amino acids: CGWY Common amino acids: E
pI: 4.86 Basic residues: 6
Polar residues: 5 Hydrophobic residues: 14
Hydrophobicity: -39.02 Boman Index: -8416
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 83.41
Instability Index: 6479.76 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  NA
  • Title:  NA